Structural RNA alignment by multi-objective optimization
نویسندگان
چکیده
منابع مشابه
Structural RNA alignment by multi-objective optimization
MOTIVATION The calculation of reliable alignments for structured RNA is still considered as an open problem. One approach is the incorporation of secondary structure information into the optimization criteria by using a weighted sum of sequence and structure components as an objective function. As it is not clear how to choose the weighting parameters, we use multi-objective optimization to cal...
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Multi-objective pairwise RNA sequence alignment
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During the last few years new functionalities of RNA have been discovered, renewing the need for computational tools for their analysis. To this respect, multiple sequence alignment is an essential step in finding structurally conserved regions in related RNA sequences. In contrast to proteins, many classes of functionally related RNA molecules show a rather weak sequence conservation but inste...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2013
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btt188